“ All spell casters gain their abilities through a form of demon possession. So in order to gain magical abilites, PCs must track down and trap demons. Of course there are some pretty powerful demons, if the demon is stronger than the PC, the PC could find themselves subjugated to the Demon's will.”
“ You find a patch of edible funghi. They taste well and all, no ill effects. UNLESS you consume some beverage, even 3 (three) days after eating it. Then you become really sick with pains, vomiting, all the fancy stuff. As a gift or good meal, it could be a cruel joke or to make sure the heroes spend their time focused on the mission. And the fine soup you had in the inn yesterday could have some in.
(Inspired through a real-world fungus. Was really used to cure alcoholism.)”
“ The devil's wind. Explains why people become crazy. They are caught up in this wind which steals their sanity which in turn feeds the wind. The wind is a leftover from when the air elementals banded together in a mass army at one point to attack the True Gods. The wind is leftover of their attack route and on the anniversary of the battle the wind sweeps through causing the madness.”